clinical trial Archives - HHO Hunterdon Hematology Oncology

Have you ever wondered where all of the cancer treatments that are available to you came from? All of these treatments were once a clinical trial, which allowed their effectiveness and safety to be determined on a small population. There are constantly new trials going on, and joining one can benefit you in a number of ways.

At Hunterdon Oncology and Hematology, the team helps you get the expert treatment you need when you’re suffering from cancer or blood disorders. Leading our team are five highly trained board-certified oncologists and hematologists who are happy to offer the latest clinical trials for a number of disorders.

What are clinical trials?

Clinical trials are basically research studies conducted on humans to determine the efficacy of a treatment or medical device. These studies are the main way researchers determine if a treatment is viable and safe to use in the general population.

However, clinical trials also go through several stages before the treatment is available to everyone. This not only ensures that the treatment is safe, but also that it’s effective for the condition included in the trial.

There are four official phases that every clinical trial needs to go through to become approved by the FDA. The first phase determines the safety and any side effects on a small group of people. The second phase involves more people, and aims to determine the effectiveness of the treatment, along with continuing to assess safety and side effects.

When the trial gets into stage three, it’s made available to a larger group of people, along with other populations. Dosages of a medication are also studied, along with combinations of the trial drug and other treatments. If the FDA determines that the trial has shown positive results, the treatment becomes approved for use.

Phase four happens after the FDA approves the medication or treatment in the trial. The effectiveness of the treatment, along with its safety, are still monitored on a much larger and more diverse population.

When to consider a clinical trial

Being a part of a clinical trial can be scary — but it can also open doors to treatments that could potentially change your life. But when should you consider joining one of these trials?

A good time to consider a clinical trial is when other treatments haven’t worked, and you don’t have other options. A clinical trial can give you the opportunity to try an up-and-coming treatment for your condition.

Sometimes, there aren’t any treatments available for a specific condition. A clinical trial gives you a chance at finding a viable treatment for your condition. It also gives you a chance to take your health into your own hands.

What are the benefits of a clinical trial?

There are a number of benefits when joining a clinical trial, but it’s important to weigh both the pros and cons before getting involved. Our team helps you find clinical trials that pertain to your condition and provide you with all the details to assist you with a decision.

Clinical trials offer many opportunities for a number of different cancer conditions. Some of the main benefits of joining one of these trials include:

Early access to the latest therapies

Clinical trials offer the most up-and-coming treatments that aren’t available to the public yet. If you join a clinical trial, you’ll get to experience the latest therapies and medications that could change the course of your cancer.

You get to help others

When you participate in a clinical trial, you have the opportunity to pave the way for future patients with the same medical problem. You’re a part of groundbreaking research that could provide a cure or effective therapy for others down the road.

More frequent checkups and care

You’re often more closely monitored when you participate in a clinical trial. This is because the research team needs to observe the way the medication or therapy is affecting your condition. This includes more frequent appointments and imaging studies, which can help to put your mind at ease.

Less cost to you

In most cases, you won’t have to pay for the drugs in your clinical trial. The team conducting the trial often covers the cost of the medication or therapy being tested. However, it’s important to remember that there could be other costs involved, such as travel or lodging, that you’ll need to cover.

If you’d like to learn more about participating in a clinical trial, call our office in Flemington, New Jersey at 908-788-6461, or schedule an appointment online with one of our expert doctors today.

Clinical trials exist for many different types of medical treatments and products. These trials are a way for doctors and patients to test the most up-to-date and state-of-the-art treatments available for a disease. Cancer clinical trials are a way for you to participate in a study while possibly improving your condition.

At Hunterdon Oncology and Hematology, our team offers a variety of clinical trials for several different types of cancer. Our practice is led by five highly trained oncologists and hematologists. Our physicians are happy to help you get started in a clinical trial specific to your form of cancer if you qualify.

What are clinical trials?

Clinical trials are research studies that involve human participants and are designed to study the effects of treatments on a certain population. The goal of the clinical trial is to evaluate how effective the drug or treatment is on the participants’ specific condition and overall health.

Clinical trials involve volunteers, meaning you sign up on your own to participate. There are often certain criteria you have to meet to be a part of such a trial. These studies are designed to test a number of different interventions in medicine, including:

Medical devices
Radiology procedures
Medications
Surgical procedures

Biological procedures and cells are other types of treatments that are involved in clinical trials. Cancer research uses clinical trials to study the outcomes of new treatments on different types of cancer. This helps to determine if a medical treatment has positive outcomes for these individuals.

Why are clinical trials important?

Clinical trials are vital to the improvement of the healthcare system. These trials allow for possible improvements in treatments and therapies for thousands of different diseases, including cancer.

Without clinical trials, medicine wouldn’t be able to move forward, with new and improved treatment options. The trials allow for potential cures, and for an overall improved outcome of millions of patients across the country.

These trials also allow us to see if the benefits of a potential treatment outweigh the side effects or risks. The different phases of clinical trials determine the side effects among a large group of people, to see if the treatment is worth it in the end.

If you’re suffering from a specific type of cancer, a clinical trial could be a way for you to get a new type of treatment when others haven’t helped. It gives you a chance to get the newest treatments available when the trial is focused on your type of cancer.

The different phases of clinical trials

Clinical trials go through several different phases before the treatment can be considered for approval for large-scale use. Each phase uses volunteers to test out the treatment and to determine if it’s safe for use. The four phases that clinical trials go through include:

Phase 1

The first phase of a clinical trial is to ensure first and foremost that the drug or treatment is safe for humans. It allows the researchers to determine a safe dosage for medications, and to learn how the treatment works within your body. This phase also identifies any adverse effects, and only involves a small number of participants.

Phase 2

Once the drug or treatment is determined to be safe, it can move into phase two of the trial. This phase is similar to phase one, but it requires a larger number of participants. This helps to determine the adverse effects on a larger number of people, to determine if the treatment is viable.

Phase 3

After the second phase has been completed, and the treatment is still being considered for widespread use, phase three of the clinical trial begins. In this stage, the drug or treatment is studied on a much larger scale. It involves many more participants, and is conducted in other regions and other countries. This is often the phase that occurs right before the treatment is considered for approval.

Phase 4

This phase occurs after the treatment or drug has been approved for use by a governing body, such as the FDA. Even though it’s been approved for use, there still may be aspects that need to be studied on more people over a longer timeframe. It can involve thousands of participants, and allows for more research into important information that still needs to be learned about the treatment.

At our facility, our team offers a number of different clinical trials if you suffer from conditions such as multiple myeloma, myelofibrosis, and polycythemia vera. Our doctors help you figure out if a clinical trial could help you.

If you’re interested in learning more about clinical trials for your condition, call our office in Flemington, New Jersey at 908-788-6461, or schedule an appointment online with one of our expert doctors today.

Cancer is a ruthless and exhausting disease, especially after you’ve been through several rounds of treatment. Chemotherapy and radiation are two very well-known treatment options, but what happens when those don’t do the trick, or aren’t warranted for your type of cancer? At that point, a clinical trial could be just the answer you’ve been looking for.

At Hunterdon Hematology Oncology, our staff members are willing to do whatever it takes to get you the type of treatment you need. Our team of five expert oncologists and hematologists participate in several types of clinical trials to get you the most up-to-date treatment options for your condition.

What are clinical trials?

There are many different types of cancer, each with its own specific treatment approach. However, the type of treatment you receive is highly dependent on how early the cancer was caught, along with other factors like your overall health.

Cancer research is constantly evolving, meaning treatments also evolve as more information is learned about each disease. This is where clinical trials come in to help when you have exhausted other options.

Clinical trials are research-based study groups that use the best and most effective treatment option for a specific type of cancer, but add in another component to hopefully yield even better results. This not only includes a trial of different medications, but it may also include therapies such as radiation or chemo.

Because research is constantly evolving, there’s literally a trial for just about any type of cancer you can think of. Many of these trials focus on later stages of cancer that are harder to beat; however, clinical trials exist for earlier stages as well.

Are you a candidate?

Now that you know what a clinical trial is, how do you know if you’re a good fit for one? This is a decision you need to think carefully about, as it’s about your life and your health. Our doctors are available to answer any questions you have and give you information on the latest clinical trials, as well as benefits and complications from each.

Here are a few guidelines to help you determine if a trial is right for you:

Having a specific type of cancer
Being in a specified stage of that cancer
Being in a certain age group
Having genetic changes in your tumor
Looking at your past medical history

The trial may also take into account your current health status, as the drugs and treatments might not be good for you if you aren’t healthy enough. They may also need to know what types of treatments you’ve tried in the past, and the results those treatments had.

Because there are so many different types of clinical trials for cancer, each one has its own set of criteria in order for you to participate. If you’re accepted into a trial, it’s a chance for you to receive treatment that you might not get anywhere else.

Pros and cons of clinical trials

Just like any other form of treatment, clinical trials have pros and cons you should weigh before you make your decision. Your health is very important, so making sure the pros outweigh the cons is your best chance at getting the results you want.

Clinical trials offer a lot of hope to those who are dealing with difficult types of cancer. Some of the benefits of these trials include:

You get the newest, most advanced treatments
Our team follows you very closely
You’ll be the first to benefit if it’s effective
Your results can help others in the future

The chance to get to try a new treatment with promising results may draw you toward a clinical trial, but unfortunately there are cons to consider as well. Some of the negative aspects of clinical trials include:

The side effects could be worse than what you have
You might not see any results
You usually have to undergo more testing than normal
You may incur additional expenses with a trial
Your insurance may not cover the trial

Sometimes, the original treatment yields better results, but that’s why the trials are in place. You should always weigh your options with our team before making a decision.

If you’ve been diagnosed with cancer and haven’t had success with your treatment, call our office in Flemington, New Jersey at 908-788-6461 to schedule an appointment with one of our amazing doctors today.

According to the American Cancer Society, lung cancer is the second most common cancer among men and women and the leading cause of death in the United States. In 2014, it is estimated that 224,210 people will be diagnosed with lung cancer. Hunterdon Regional Cancer Center was selected as the only cancer facility in New Jersey to offer a clinical study on a new lung cancer investigational drug called Nivolumab, which is made by Bristol-Myers Squibb.

“This clinical study uses immuno-therapy as a new approach for treating lung cancer. This therapy uses the patient’s own immune system to attack the cancer cells,” stated Myron Bednar, M.D., Medical Oncologist, Hunterdon Regional Cancer Center. Dr. Bednar further explained, “Nivolumab works by blocking the protein called PD-1. The PD-1 antibodies stop lung cancer cells from blocking the body’s natural immune response to cancer. A drug that can inhibit PD-1 may be able to treat a variety of cancers, which is very exciting.”

Patients who may be eligible for the study have been diagnosed with advanced stage lung cancer and have undergone at least one therapy prior to entering this trial. “The benefit from standard therapy is limited for this patient population. Our hope is that this drug will keep the cancer from growing and have the patient’s immune system do the work of killing the cancer cells, versus drugs that may have many side effects, said Kenneth Blankstein, Medical Oncologist at Hunterdon Regional Cancer Center. Dr. Blankstein also mentioned, “We are pleased to be able to provide this trial in our community. We are not only the only cancer facility in New Jersey testing this drug in a clinical trial, but the only one in the tri-state area. The next closest facility is in Tennessee.”

Pictured left to right: Kathy Robbins, RN, MSN, OCN, Clinical Research Nurse at Hunterdon Regional Cancer Center works closely with patients on clinical trials. Kathy talks to Daria Shepherd and provides comfort and education during her treatment at Hunterdon Regional Cancer Center.

Daria Shepherd of Kingwood Township was diagnosed with advanced stage lung cancer in December. Ms. Shepherd had gone to her family doctor because of a pain she was having on her side. An ultrasound showed that the pain was the result of a cyst on her ovary, but the test also found a spot on her lung. A chest scan and a biopsy determined it was cancer. “I started chemotherapy, but it wasn’t effective for my type of cancer, so Dr. Bednar thought I would be an ideal candidate for the Nivolumab clinical trial,” stated Ms. Shepherd. Shepherd added, “This is my second week receiving the drug and I feel good, it has not had any side effects that have interfered with my life.” In fact, Ms. Shepherd was heading out to Spruce Run to fish with her family after her treatment.

Through Hunterdon Regional Cancer Center’s partnership with Fox Chase Cancer Center in Philadelphia, physicians have access to many clinical research trials, which are administered by specially trained staff. Current trials offered at Hunterdon Regional Cancer Center include new treatment protocols for lung cancer, breast, gastrointestinal cancers, as well as lymphoma and melanoma. To learn more about clinical trials at Hunterdon Regional Cancer Center, call Kathy Robbins, RN, MSN, OCN, Clinical Research Nurse at Hunterdon Regional Cancer Center at 908-237-2330 ext. 2.

By Martta Kelly | Special to The Star-Ledger

Lung cancer patient Daria Shepherd smiles as she looks at her daughter, Paige, Shepherd as Daria receives a new trial cancer treatment called Nivolumab at the Hunterdon Regional Cancer Center in Flemington. (Tony Kurdzuk/The Star-Ledger)

A routine ultrasound last year turned out to be something much more sinister for Daria Shepherd of Kingwood Township.

“I had this pain in my right side and I thought it was just the result of overdoing it,” said the active 47-year-old mother of two who enjoys jogging regularly with her 22-year-old daughter.

When her blood tests came back normal and physical therapy didn’t seem to be helping, her doctor ordered the ultrasound.
Shepherd wasn’t prepared for what came next.

The ultrasound showed not only a benign cyst on her right ovary but spots on her lung as well. A subsequent chest scan and biopsy determined the spots indicated advanced lung cancer.

Shepherd started chemotherapy, but it proved to be ineffective for her type of cancer. Her doctor, Myron E. Bednar, medical oncologist at Hunterdon Regional Cancer Center in Flemington, suggested she enroll in a clinical trial for a new drug called Nivolumab, which works with the patient’s own immune system to attack cancer cells. In addition, the drug doesn’t have the debilitating side effects of traditional chemotherapy, such as nausea, fatigue and hair loss.

Oncologist Myron Bednar checks on Daria Shepherd as she receives Nivolumab at the Hunterdon Regional Cancer Center. (Tony Kurdzuk/The Star-Ledger)

Lung cancer, according to the American Cancer Society, is the second most common cancer among men and women and the leading cause of death in the United States. It is estimated that this year, more than 224,000 people will be diagnosed with lung cancer.

HRCC was selected as the only cancer facility in New Jersey to offer a clinical study on Nivolumab, which is made by Bristol-Myers Squibb. The closest facility outside the tri-state area is in Tennessee. There are currently eight people in the clinical trial at HRCC.

To be eligible for the clinical trial, patients must have been diagnosed with advanced stage lung cancer and have undergone at least one therapy prior to entering the trial, Bednar said.

Nivolumab works by blocking a molecule called PD-L1, found in many cancer cells, from binding to a protein called PD-1, found on the surface of T-cells, known as the “fighter cells” of the immune system, said Kenneth B. Blankstein, an oncologist at HRCC.

If PD-L1 is allowed to bind to PD-1, T-cells become ineffective, Blankstein explained. This is how cancer cells are able to disarm T-cells and inhibit them from attacking the tumor. Since PD-1 blockers free up the immune system only around the tumor rather than throughout the whole body, they also have fewer side effects than chemotherapy.

“Drugs such as Nivolumab that inhibit PD-1 may also be able to treat a variety of cancers, including melanoma, which is very exciting.” Blankstein added.
Both Bednar and Blankstein stressed that while Nivolumab, like chemotherapy, is not a cure, it appears to improve the overall survival of cancer patients.

“We’re are optimistic about the results of the trial so far,” Bednar said. “We’ve had a 30 percent response rate, which, in this group, is significant.”

To date, Shepherd has had three infusion treatments and feels wonderful. She is scheduled to have a CAT scan every eight weeks to see how things are responding. “I have not had any side effects whatsoever,” she said. “I have been able to go on with my life and to do the things I love, such as fishing and jogging.”

Anyone interested in becoming part of this clinical trial should call Hunterdon Regional Cancer Center, (908)-788-6461, and ask to speak with Kathy Robbins, a clinical research nurse. If it is determined that you are eligible, she will set up an appointment with one of center’s four oncologists.

HHO News

The Benefits of Joining a Clinical Trial

What are clinical trials?

When to consider a clinical trial

What are the benefits of a clinical trial?

Early access to the latest therapies

You get to help others

More frequent checkups and care

Less cost to you

The Four Phases of Clinical Trials

What are clinical trials?

Why are clinical trials important?

The different phases of clinical trials

Phase 1

Phase 2

Phase 3

Phase 4

Should You Join a Clinical Trial?

What are clinical trials?

Are you a candidate?

Pros and cons of clinical trials

The Only Cancer Center in New Jersey to Offer Immunotherapy Clinical Trial for Lung Cancer

Lung cancer treatment using patients’ immune system shows promise

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